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Call–Exner bodies marked with black circles in an intermediate-high magnification micrograph of a granulosa cell tumour, a type of sex cord stromal tumour. H&E stain. H&E stain. Call–Exner bodies , giving a follicle-like appearance, are small eosinophilic fluid-filled punched out spaces between granulosa cells . [ 1 ]
Histopathologic types of kidney tumor, with relative incidences and prognoses. Cystic nephroma is seen at bottom right in pie chart. cystic partially differentiated nephroblastoma; cystic standard nephroblastoma (cystic Wilm's tumor) cystic mesoblastic nephroma; cystic renal cell carcinoma; other renal cysts
Umbrella cells are usually present in low-grade tumors [13] Frequently branching fibrovascular cores [13] Frequently fusing of papillae [13] Not recommended [1] Small-cell carcinoma 0.3–2% [14] [15] [notes 1] Small blue cells with scant cytoplasm [1] High nucleus/cytoplasm ratio [1] "salt and pepper" chromatin [1] Nuclear molding [1]
Serous cystadenomas can be further sub-typed into microcystic, oligocystic (or macrocystic), solid, mixed serous-endocrine neoplasm, and VHL-associated serous cystic neoplasm. This latter classification scheme is useful because it highlights the range of appearances and the clinical associations of these neoplasms.
Desmoplastic small-round-cell tumor (DSRCT) is an aggressive and rare cancer that primarily occurs as masses in the abdomen. [4] Other areas affected may include the lymph nodes, the lining of the abdomen, diaphragm, spleen, liver, chest wall, skull, spinal cord, large intestine, small intestine, bladder, brain, lungs, testicles, ovaries, and the pelvis.
Pancreatic mucinous cystic neoplasm (MCN) is a type of cystic lesion that occurs in the pancreas.Amongst individuals undergoing surgical resection of a pancreatic cyst, about 23 percent were mucinous cystic neoplasms.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs arise in the smooth muscle pacemaker interstitial cell of Cajal, or similar cells. [2] They are defined as tumors whose behavior is driven by mutations in the KIT gene (85%), [2] PDGFRA gene (10%), [2] or BRAF kinase (rare).
The 5th WHO classification delineates distinct types of tumors, some of them being further divided into subtypes, rendering the former terms entity and variant obsolete. When molecular diagnostics are not complete enough to allow precise classification, diagnosis should be designated by appending not otherwise specified (NOS).