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Protein toxicity is the effect of the buildup of protein metabolic waste compounds, like urea, uric acid, ammonia, and creatinine.Protein toxicity has many causes, including urea cycle disorders, genetic mutations, excessive protein intake, and insufficient kidney function, such as chronic kidney disease and acute kidney injury.
Samoyeds can be affected by basement membrane disease of the kidneys. It is inherited through the X chromosome and is therefore more severe in affected male dogs. Findings in male dogs include the presence of protein and glucose in the urine and the inability to concentrate urine, and progression to kidney failure by the age of 9 months and death by 16 months. [3]
[25] [29] [30] After 14 weeks of age, protein requirements decrease to 200 g/kg of diet (20% of the diet) for optimal growth. [6] [31] [32] [33] Protein in excess of these levels is metabolized and leads to an increase of the glomerular filtration rate, and increased urea excretion in the urine, with no evidence of damage to the kidneys. [34]
The FDA has released a list of the people foods that, when fed to dogs, present a high risk of problems. SEE ALSO: Adorable French bulldog cools down from the summer heat
Acetaminophen (paracetamol, Tylenol) can cause liver damage in dogs. The toxic dose is 150 mg/kg. [174] Ibuprofen * can cause gastrointestinal irritation, stomach ulcers, and kidney damage in dogs. [175] Naproxen (Aleve)* has a long half-life in dogs and can cause gastrointestinal irritation, anemia, melena (digested blood in feces), and vomiting.
Liver disease, malnutrition, kidney disease Aminoaciduria occurs when the urine contains abnormally high amounts of amino acids . [ 2 ] In the healthy kidney, the glomeruli filter all amino acids out of the blood, and the renal tubules then reabsorb over 95% of the filtered amino acids back into the blood.
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