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Micrograph of a basal-cell carcinoma, showing the characteristic histomorphologic features (peripheral palisading, myxoid stroma, artefactual clefting). H&E stain Basal-cell carcinoma is named after the basal cells that populate the lowest layer of the epidermis due to the histological appearance of the cancer cells under the microscope. [ 16 ]
Palisading in nodular basal-cell carcinoma. Palisades that are generally longer than a rosette or pseudorosette can be seen in neural tumors such as Schwannoma, [16] [17] as well as in ameloblastomas. They can also be seen in nodular basal-cell carcinomas. [18]
Basaloid forms of lung carcinoma were first described in the peer-reviewed medical literature by Dr. Elisabeth Brambilla and her colleagues in 1992. [11] They were first recognized as distinct clinicopathological variants of both squamous cell and large cell lung cancers in 1999, within the third revision of the World Health Organization lung tumor typing and classification scheme.
In the case of Bas-SqCC, it is essential that both evidence of squamous differentiation (i.e., intercellular bridges, production of keratin, tonofilament bundles) and basaloid architecture (i.e. prominent peripheral palisading of cell nuclei, organoid/lobular structures) are identified to make a correct diagnosis. [3] [7]
Basal-cell carcinoma 0.01% [17] Basaloid tumor: Scant cytoplasm [1] High nucleus/cytoplasm ratio [1] Irregular or angulated nuclei [1] Euchromatic [1] May have nuclear and cytoplasmic micro-vacuolation [1] Infiltration of adjacent parenchyma [1] BCC-pattern: Variably sized solid nests, cords, or trabeculae [1] Peripheral palisading [1] p63+ [1 ...
Both patterns have basaloid cells arranged in solid nests, nodules or trabecula, with focal peripheral palisading. The nuclei are round to oval with delicate chromatin and a usually single nucleolus. Ductules can sometimes be seen. The background stroma is loose, immature and sometimes myxoid. Necrosis can be present.