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Cannabidiol (CBD) is a ... Side effects of CBD are dose related. [50] ... In February 2020, the UK FSA advised vulnerable people, such as pregnant women ...
Cannabitriol (CBT) is a phytocannabinoid first isolated in 1966, [1] [2] [3] an oxidation product of tetrahydrocannabinol (THC) which has been identified both as a trace component of cannabis and as a metabolite in cannabis users. [4]
Charlotte's Web is a brand of high-cannabidiol (CBD), low-tetrahydrocannabinol (THC) products derived from industrial hemp and marketed as dietary supplements and cosmetics under federal law of the United States. [1] [2] [3] It is produced by Charlotte's Web, Inc. in Colorado.
In dogs, the minimum lethal dose of THC is over 3000 mg/kg. [20] According to The Merck Index , [ 21 ] the LD 50 of THC (the dose which causes the death of 50% of individuals) is 1270 mg/kg for male rats and 730 mg/kg for female rats from oral consumption in sesame oil, and 42 mg/kg for rats from inhalation.
Cannabidiol has little affinity for CB 1 and CB 2 receptors but acts as an indirect antagonist of cannabinoid agonists. [25] It was found to be an antagonist at the putative new cannabinoid receptor, GPR55, a GPCR expressed in the caudate nucleus and putamen. [26] Cannabidiol has also been shown to act as a 5-HT 1A receptor agonist. [27]
7-Hydroxycannabidiol (7-OH-CBD) is an active metabolite of cannabidiol, generated in the body from cannabidiol by the action of the enzyme CYP2C19. [1] While methods have been developed for its synthetic production, [2] and measurement of levels in the body following consumption of cannabidiol, [3] its pharmacology has been relatively little studied, though it has been found to possess similar ...
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It is related to cannabidiol, with the pentyl side chain shortened to a methyl group. Cannabidiorcol has low affinity for cannabinoid receptors and is mainly active as an agonist of the TRPV2 cation channel, through which it produces antiinflammatory effects, [ 1 ] but can also promote tumorigenesis at high concentrations.