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ALDH2 pictured on the left, is an enzyme which breaks down acetaldehyde. [20] [21] Regions highlighted in yellow are structural and allow ALDH2 to fold properly. [20] [21] The region highlighted in red can vary between individuals (right). [22] Individuals who have a G in their DNA will have normal folding and function of ALDH2. [20]
The reaction is the result of an accumulation of acetaldehyde, a metabolic byproduct of the catabolic metabolism of alcohol, and is caused by an aldehyde dehydrogenase 2 deficiency. [ 4 ] This syndrome has been associated with lower than average rates of alcoholism, possibly due to its association with adverse effects after drinking alcohol. [ 5 ]
ALDH2 is a tetrameric enzyme that contains three domains; two dinucleotide-binding domains and a three-stranded beta-sheet domain. The active site of ALDH2 is divided into two halves by the nicotinamide ring of nicotinamide adenine dinucleotide (NAD +).
Foods to avoid. In addition to consuming liver-friendly foods, reducing a few that may harm the liver can also help. Alcohol: This one is the most obvious offender of good liver health, and ...
Generally, however, these guidelines agree that highly processed foods contain high amounts of total and added sugars, fats, and/or salt, low amounts of dietary fiber, use industrial ingredients ...
Nutritionists and dietitians share healthy eating tips and the foods they avoid. Steer clear of processed food high in sugar and salt, and find ways to make vegetables enjoyable.
ALDH2, which has a lower K M for acetaldehydes than ALDH1 and acts predominantly in the mitochondrial matrix, is the main enzyme in acetaldehyde metabolism and has three genotypes. A single point mutation (G → A) at exon 12 of the ALDH2 gene causes a replacement of glutamate with lysine at residue 487, resulting in the ALDH2K enzyme. [8]
Losing weight is often about that ideal combination of diet and exercise. Choosing the right foods can be just as important as avoiding certain ones. So be sure to steer clear of the foods below.