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Worldwide, around 65% of adults are affected by lactose malabsorption. [5] [8] Other mammals usually lose the ability to digest lactose after weaning. Lactose intolerance is the ancestral state of all humans before the recent evolution of lactase persistence in some cultures, which extends lactose tolerance into adulthood. [9]
Lactase persistence or lactose tolerance is the continued activity of the lactase enzyme in adulthood, allowing the digestion of lactose in milk. In most mammals , the activity of the enzyme is dramatically reduced after weaning . [ 1 ]
Lactase produced commercially can be extracted both from yeasts such as Kluyveromyces fragilis and Kluyveromyces lactis and from molds, such as Aspergillus niger and Aspergillus oryzae. [7] Its primary commercial use in supplements is to break down lactose in milk to make it suitable for people with lactose intolerance.
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She explains that “for most people, a moderate amount, such as half a cup to a cup per day, can be enough to experience benefits. However, it can vary based on individual gut health and tolerance.
This is an autosomal recessive disorder and infants that can’t break down lactose have trouble with breastmilk, and develop diarrhea starting from birth. Sometimes, even those with lactase-persistence can develop temporary lactose intolerance as a result of infection or inflammation in the small intestine.
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