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Spironolactone usually available in tablets, taken by mouth, though topical forms are also available. [4] Common side effects include electrolyte abnormalities, particularly high blood potassium, nausea, vomiting, headache, rashes, and a decreased desire for sex. [4] In those with liver or kidney problems, extra care should be taken. [4]
Other side effects include liver inflammation, methemoglobinemia, [7] and a number of types of skin rashes. [4] While the safety of use during pregnancy is not entirely clear some physicians recommend that it be continued in those with leprosy. [4] It is of the sulfone class. [4] Dapsone was first studied as an antibiotic in 1937. [5]
A skin biopsy, blood tests or immunological tests can also be useful. Drug reactions have characteristic timing. The typical amount of time it takes for a rash to appear after exposure to a drug can help categorize the type of reaction. For example, Acute generalized exanthematous pustulosis usually occurs within 4 days of starting the culprit ...
Spironolactone has been identified as an inhibitor of NRG1‐ERBB4 signaling. [142] Spironolactone has been found to act as a potent inhibitor of the pannexin 1 channel, and this action appears to be involved in its antihypertensive effects independently of MR antagonism. [143] Spironolactone has been found to block hERG channels. [144]
Perioral dermatitis: This is a rash that occurs around the mouth and the eye region that has been associated with topical steroids. Ocular effects: Topical steroid drops are frequently used after eye surgery but can also raise intraocular pressure (IOP) and increase the risk of glaucoma , cataract , retinopathy as well as systemic adverse effects.
Pityriasis rosea is a type of skin rash. [2] Classically, it begins with a single red and slightly scaly area known as a "herald patch". [2] This is then followed, days to weeks later, by an eruption of many smaller scaly spots; pinkish with a red edge in people with light skin and greyish in darker skin. [4]
[10] [96] It is an analogue of other spirolactones like spironolactone, canrenone, and spirorenone. [10] [96] Drospirenone differs structurally from spironolactone only in that the C7α acetyl thio substitution of spironolactone has been removed and two methylene groups have been substituted in at the C6β–7β and C15β–16β positions. [97]
Dermatitis is a term used for different types of skin inflammation, typically characterized by itchiness, redness and a rash. [1] In cases of short duration, there may be small blisters, while in long-term cases the skin may become thickened. [1]