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Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1]
Extended-release (or slow-release) formulations of morphine are those whose effect last substantially longer than bare morphine, availing for, e.g., one administration per day. Conversion between extended-release and immediate-release (or "regular") morphine is easier than conversion to or from an equianalgesic dose of another opioid with ...
Nicotine patches are applied to the skin and continuously administer a stable dose of nicotine slowly over 16–24 hours. [ 19 ] [ 41 ] Nicotine gum , nicotine sprays, nicotine toothpicks, nicotine sublingual tablets, and nicotine lozenges administer nicotine orally with quicker nicotine uptake into the body but lasting a shorter amount of time ...
Medikinet Retard/CR/Adult/Modified Release tablets are an extended-release oral capsule form of methylphenidate. It delivers 50% of the dosage as IR MPH and the remaining 50% in 3–4 hours. [185] [186] Jornay PM is a delayed release formulation that is taken at bedtime.
Self-microemulsifying drug delivery system; Sink condition; Smoking; Snuff (tobacco) Softgel; Sol–gel process; Solution (chemistry) Subcutaneous administration; Suppository; Suspension (chemistry) Modified-release dosage; Syrup
Molindone [extended-release] (AFX-2201, EN-1733A, molindone XR, SPN-810, SPN-810M, Zalvari) – antipsychotic / dopamine D 2 receptor antagonist and serotonin receptor modulator (e.g., serotonin 5-HT 2B and 5-HT 2A receptor antagonist) — specifically under development for impulsive aggression in ADHD [6] [7] [8]
Depot injections can be created by modifying the drug molecule itself, as in the case of prodrugs, or by modifying the way it is administered, as in the case of oil/lipid suspensions. Depot injections can have a duration of action of one month or greater and are available for many types of drugs, including antipsychotics and hormones .
A nicotine lozenge is a modified-release dosage tablet (usually flavored) that contains a dose of nicotine polacrilex, which dissolves slowly in the mouth to release nicotine over the course of 20 to 30 minutes. Nicotine lozenges are intended to help individuals quit smoking and are generally an over-the-counter medication.