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Progynova (estradiol valerate) 1 mg oral tablets in the Chinese mainland. Side effects of estradiol valerate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [15] [13] [14] Estradiol valerate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol.
Oral micronized estradiol valerate tablets can be taken sublingually as well. [167] [168] The administration of 2 mg oral micronized estradiol valerate tablets (Progynova, Schering) sublingually 3 or 4 times per day resulted in circulating estradiol levels of about 290 pg/mL to 460 pg/mL in premenopausal women (time of measurements not given).
In 1966, oral estradiol valerate was introduced by Schering for medical use under the brand name Progynova. [32] [33] [213] [214] Esterification of estradiol, as in estradiol valerate, was believed to improve its metabolic stability with oral administration.
In general, generic estradiol cream may be more affordable than brand-name versions. This is because, as per the Food and Drug Administration (FDA), generic drugs may cost around 80% to 85% less ...
Estradiol valerate: Progynova: Estrogen: Oral: 2–10 mg/day Progynova: Estrogen: Sublingual: 1–8 mg/day Delestrogen [c] Estrogen: IM, SC: 2–10 mg/wk or 5–20 mg every 2 wks Estradiol cypionate: Depo-Estradiol: Estrogen: IM, SC: 2–10 mg/wk or 5–20 mg every 2 wks Estradiol dipropionate: Agofollin: Estrogen: IM, SC: 2–10 mg/wk or 5 ...
Estradiol valerate (Delestrogen, Progynon Depot, Progynova; Gravibinon, Mesigyna, Mesygest) Polyestradiol phosphate (Estradurin) (an estradiol ester in polymeric form) And the following less commonly used esters: [1] [2] Cloxestradiol acetate (Genovul; diacetate ester of cloxestradiol, or estradiol 17β-chloral hemiacetal ether)
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