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DNA origami was the cover story of Nature on March 16, 2006. [3] Since then, DNA origami has progressed past an art form and has found a number of applications from drug delivery systems to uses as circuitry in plasmonic devices; however, most commercial applications remain in a concept or testing phase. [4]
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Among these devices are force-sensing nano-structures, [2] gigadalton-sized DNA assemblies, [3] dynamically switching devices, [4] molecular motors, [5] [6] and virus traps. [ 7 ] [ 8 ] In the long term, Dietz hopes to make a significant contribution to the creation of molecular machines and systems with practical benefits for everyday life.
These include examples such as DNA machines, periodic two- and three-dimensional lattices, polyhedra, and DNA origami. [2] It can also be used to create sets of nucleic acid strands which are "orthogonal", or non-interacting with each other, so as to minimize or eliminate spurious interactions.
As a research fellow at Caltech, Rothemund has developed a technique to manipulate and fold strands of DNA known as DNA origami. Eventually, Rothemund hopes that self-assembly techniques could be used to create a "programming language for molecules, just as we have programming languages for computers."
Researchers from Seoul University, Harvard and a tire company teamed up to make a shape shifting wheel after analyzing the water bomb tessellation origami pattern.
Qian has also created complex DNA origami. [8] She created two-dimensional images from DNA origami tiles. [8] She used DNA to create an artificial neural network. [9] The network consisted of a DNA gate architecture that can be scaled up into multi-layer circuits. [9] [10]
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