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In cell biology, a phagosome is a vesicle formed around a particle engulfed by a phagocyte via phagocytosis. Professional phagocytes include macrophages, neutrophils, and dendritic cells (DCs). [1] A phagosome is formed by the fusion of the cell membrane around a microorganism, a senescent cell or an apoptotic cell.
Phagosome Formation: Once the phagocytic cup has almost completely surrounded the target, the membrane extensions seal together, forming an intact phagosome containing the engulfed material. [9] Phagosome Maturation: The newly formed phagosome undergoes a series of transitions similar to endosome maturation. This process involves the recycling ...
In detail, a phagocyte's duty is obtaining food particles and digesting it in a vacuole. [2] For example, following phagocytosis, the ingested particle (or phagosome) fuses with a lysosome containing hydrolytic enzymes to form a phagolysosome; the pathogens or food particles within the phagosome are then digested by the lysosome's enzymes.
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The phagocyte then stretches itself around the bacterium and engulfs it. Phagocytosis of bacteria by human neutrophils takes on average nine minutes. [25] Once inside this phagocyte, the bacterium is trapped in a compartment called a phagosome. Within one minute the phagosome merges with either a lysosome or a granule to form a phagolysosome.
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Phagocytosis (from Ancient Greek φαγεῖν (phagein) 'to eat' and κύτος (kytos) 'cell') is the process by which a cell uses its plasma membrane to engulf a large particle (≥ 0.5 μm), giving rise to an internal compartment called the phagosome. It is one type of endocytosis. A cell that performs phagocytosis is called a phagocyte.
Some scientists say food dyes could make behavioral issues in children worse. Lawmakers in at least 10 states want to regulate them.