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An enteric coating is a polymer barrier applied to oral medication that prevents its dissolution or disintegration in the gastric environment. [1] This helps by either protecting drugs from the acidity of the stomach, the stomach from the detrimental effects of the drug, or to release the drug after the stomach (usually in the upper tract of the intestine). [2]
Tablets, typically of about 75–100 mg and 300–320 mg of immediate-release aspirin (IR-ASA). Dispersible tablets. Enteric-coated tablets. Buffered formulations containing aspirin with one of many buffering agents. Formulations of aspirin with vitamin C (ASA-VitC) A phospholipid-aspirin complex liquid formulation, PL-ASA.
Additionally, aspirin induces the formation of NO-radicals in the body, which have been shown in mice to have an independent mechanism of reducing inflammation. This reduces leukocyte adhesion, which is an important step in immune response to infection. There is currently insufficient evidence to show that aspirin helps to fight infection. [18]
A film coating is a thin polymer-based coat that is typically sprayed onto solid pharmaceutical dosage forms, such as tablets, capsules, pellets or granules.Film coating can impact both its appearance and its pharmacokinetics making it an essential process in making the final drug product.
Encaprin was a brand of safety-coated aspirin capsules made by Procter & Gamble in the mid-1980s through its Norwich Eaton Pharmaceuticals division. In 1986, the brand was involved in a cyanide poisoning hoax, and its sales never recovered.
The acutely toxic dose of aspirin is generally considered greater than 150 mg per kg of body mass. [12] Moderate toxicity occurs at doses up to 300 mg/kg, severe toxicity occurs between 300 and 500 mg/kg, and a potentially lethal dose is greater than 500 mg/kg. [13]