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Angiotensin-converting enzyme (EC 3.4.15.1), or ACE, is a central component of the renin–angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. It converts the hormone angiotensin I to the active vasoconstrictor angiotensin II .
Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a class of medication used primarily for the treatment of high blood pressure and heart failure. [1] [2] This class of medicine works by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.
59272 70008 Ensembl ENSG00000130234 ENSMUSG00000015405 UniProt Q9BYF1 Q8R0I0 RefSeq (mRNA) NM_021804 NM_001371415 NM_001130513 NM_027286 RefSeq (protein) NP_068576 NP_001358344 NP_001123985 NP_081562 Location (UCSC) Chr X: 15.56 – 15.6 Mb Chr X: 162.92 – 162.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Angiotensin-converting enzyme 2 (ACE2) is an enzyme that can be found ...
ACE inhibitors of angiotensin-converting enzyme inhibitors are often used to reduce the formation of the more potent angiotensin II. Captopril is an example of an ACE inhibitor. ACE cleaves a number of other peptides, and in this capacity is an important regulator of the kinin–kallikrein system , as such blocking ACE can lead to side effects.
Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure. It is part of the renin–angiotensin system, which regulates blood pressure. Angiotensin also stimulates the release of aldosterone from the adrenal cortex to promote sodium retention by the kidneys. An oligopeptide, angiotensin is a hormone and a ...
Antihypertensive agents are classified according to their mechanism of actions. The most common classes prescribed are diuretics, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs) and beta-blockers. Antihyperlipidemic agents most often prescribed are statins, ezetimibe and ...
Angiotensin I is further cleaved by an enzyme that is located primarily but not exclusively in the pulmonary circulation bound to endothelium; that enzyme is angiotensin converting enzyme (ACE). This cleavage produces angiotensin II, the most vasoactive peptide. [38] [39] Angiotensin II is a potent constrictor of all blood vessels. It acts on ...
It is in the angiotensin-converting-enzyme (ACE) inhibitor family of medications. [5] Enalapril was patented in 1978, and came into medical use in 1984. [7] It is on the World Health Organization's List of Essential Medicines. [8] In 2022, it was the 141st most commonly prescribed medication in the United States, with more than 4 million ...