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Ximelagatran is a prodrug, being converted in vivo to the active agent melagatran. This conversion takes place in the liver and many other tissues through hydrolysis and dehydroxylation (replacing the ethyl and hydroxyl groups with hydrogen). The conversion of ximelagatran to melagatran. This conversion includes dealkylation and dehydroxylation.
Alpidem (Ananxyl) 1995. Worldwide. Not approved in the US, withdrawn in France in 1994 [ 4 ] and the rest of the market in 1995 because of rare but serious hepatotoxicity. [ 3 ][ 5 ] Alosetron (Lotronex) 2000. US. Serious gastrointestinal adverse events; ischemic colitis; severe constipation. [ 2 ] Reintroduced 2002 with restricted indication ...
The term ex-ante (sometimes written ex ante or exante) is a New Latin phrase meaning "before the event". [1] In economics, ex-ante or notional demand refers to the desire for goods and services that is not backed by the ability to pay for those goods and services. This is also termed as ' wants of people'. Ex-ante is used most commonly in the ...
An anticoagulant, commonly known as a blood thinner, is a chemical substance that prevents or reduces the coagulation of blood, prolonging the clotting time. [1] Some occur naturally in blood-eating animals, such as leeches and mosquitoes, which help keep the bite area unclotted long enough for the animal to obtain blood.
Direct thrombin inhibitors (DTIs) are a class of medication that act as anticoagulants (delaying blood clotting) by directly inhibiting the enzyme thrombin (factor IIa). Some are in clinical use, while others are undergoing clinical development. Several members of the class are expected to replace heparin (and derivatives) and warfarin in ...
The exact chronology of Mundaka Upanishad, like other Vedic texts, is unclear. [7] All opinions rest on scanty evidence, an analysis of archaism, style and repetitions across texts, driven by assumptions about likely evolution of ideas, and on presumptions about which philosophy might have influenced which other Indian philosophies.
A peptidomimetic is a small protein-like chain designed to mimic a peptide. [1][2] They typically arise either from modification of an existing peptide, or by designing similar systems that mimic peptides, such as peptoids and β-peptides. Irrespective of the approach, the altered chemical structure is designed to advantageously adjust the ...
Athena I. Vakali (born 1963) [1] is a Greek computer scientist whose topics of research include social networks, cloud computing, smart cities, and content delivery networks. She is a professor of informatics at Aristotle University of Thessaloniki . Vakali earned a bachelor's degree in mathematics from Aristotle University of Thessaloniki in ...