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Astrocytes (green) in the context of neurons (red) in a mouse cortex cell culture 23-week-old fetal brain culture human astrocyte Astrocytes (red-yellow) among neurons (green) in the living cerebral cortex. Astrocytes are a sub-type of glial cells in the central nervous system. They are also known as astrocytic glial cells.
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SGCs are present in the PNS in fewer numbers than other more well-known types of glial cells, like astrocytes, but have been determined to affect nociception because of some of their physiological and pharmacological properties. [21] In fact, just like astrocytes, SGCs have the ability to sense and regulate neighboring neuronal activity. [30]
The Spanish scientist Santiago Ramón y Cajal defined a "third element" (cell type) besides neurons and astrocytes. [13] Pío del Río Hortega, a student of Santiago Ramón y Cajal, first called the cells "microglia" around 1920.
Evidence for the role of astrocytes in the integration and processing of synaptic integration presents itself in a number of ways: Astrocytes are excitable cells: In response to stimuli from any of the three components of the tripartite synapse, astrocytes are capable of producing transient changes in their intracellular calcium concentrations through release of calcium stores from the ...
Glia are grouped into macroglia – astrocytes, ependymal cells, and oligodendrocytes, and much smaller microglia which are the macrophages of the central nervous system. Astrocytes are seen to be capable of communication with neurons involving a signalling process similar to neurotransmission called gliotransmission. [4]
After injury, astrocytes undergo morphological changes, extend their processes, and increase synthesis of glial fibrillary acidic protein (GFAP). GFAP is an important intermediate filament protein that allows the astrocytes to begin synthesizing more cytoskeletal supportive structures and extend pseudopodia. Ultimately, the astrocytes form a ...
Astrogliosis (also known as astrocytosis or referred to as reactive astrogliosis) is an abnormal increase in the number of astrocytes due to the destruction of nearby neurons from central nervous system (CNS) trauma, infection, ischemia, stroke, autoimmune responses or neurodegenerative disease.