Search results
Results From The WOW.Com Content Network
Modulating the pyrimidine metabolism pharmacologically has therapeutical uses, and could implement in cancer treatment. [ 10 ] Pyrimidine synthesis inhibitors are used in active moderate to severe rheumatoid arthritis and psoriatic arthritis , as well as in multiple sclerosis .
Pyrimidine (C 4 H 4 N 2; / p ɪ ˈ r ɪ. m ɪ ˌ d iː n, p aɪ ˈ r ɪ. m ɪ ˌ d iː n /) is an aromatic, heterocyclic, organic compound similar to pyridine (C 5 H 5 N). [3] One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has nitrogen atoms at positions 1 and 3 in the ring.
Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug , [8] used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. [9] Bottle of Leflunomide (Arava) and tablet
Orotic aciduria (AKA hereditary orotic aciduria) is a disease caused by an enzyme deficiency, resulting in a decreased ability to synthesize pyrimidines.It was the first described enzyme deficiency of the de novo pyrimidine synthesis pathway.
Another term used to describe these disorders is "enzymopathies". This term was created following the study of biodynamic enzymology , a science based on the study of the enzymes and their products. Finally, inborn errors of metabolism were studied for the first time by British physician Archibald Garrod (1857–1936), in 1908.
Download as PDF; Printable version; In other projects Wikidata item; ... Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines.
Purines are biologically synthesized as nucleotides and in particular as ribotides, i.e. bases attached to ribose 5-phosphate.Both adenine and guanine are derived from the nucleotide inosine monophosphate (IMP), which is the first compound in the pathway to have a completely formed purine ring system.
Alloxan, sometimes referred to as alloxan monohydrate, is an organic compound with the formula OC(NHCO) 2 C(OH) 2.It is classified as a derivative of pyrimidine.The anhydrous derivative OC(NHCO) 2 CO is also known, as well as a dimeric derivative.