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3,4-dichloromethylphenidate (abbreviated as 3,4-DCMP, and incorrectly as 3,4-CTMP for the d,l-threo diastereomer) is a potent stimulant drug from the phenidate class closely related to methylphenidate. It acts as a potent serotonin-norepinephrine-dopamine reuptake inhibitor with a long duration of action. It has been sold online as a designer drug.
293 n/a Ensembl ENSG00000169100 n/a UniProt P12236 Q6I9V5 n/a RefSeq (mRNA) NM_001636 n/a RefSeq (protein) NP_001627 NP_001627.2 n/a Location (UCSC) Chr X: 1.39 – 1.39 Mb n/a PubMed search n/a Wikidata View/Edit Human ADP/ATP translocase 3, also known as solute carrier family 25 member 6, is a protein that in humans is encoded by the SLC25A6 gene. Identical copies of this gene reside on the ...
In enzymology, a [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] (EC 2.7.11.4) is an enzyme that catalyzes the chemical reaction ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] ⇌ {\displaystyle \rightleftharpoons } ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
The attention went to create ATP analogues with higher potency and stability. These analogues had very short half-life due to retention of the triphosphate groups and thus needed to be given IV. Modification of these analogues led to the discovery of ticagrelor, a selective and stable non-phosphate P2Y 12 receptor antagonist. [ 9 ]
The ANT4 protein is a mitochondrial ADP/ATP carrier that catalyzes the exchange of ADP and ATP between the mitochondrial matrix and cytoplasm during ATP synthesis. [6] In addition, ANT4 stabilizes the mitochondrial membrane potential and decreases the permeability transition pore complex (PTPC) opening in order to prevent nuclear chromatin fragmentation and resulting cell death. [7]
Steps 1 and 3 require the input of energy derived from the hydrolysis of ATP to ADP and P i (inorganic phosphate), whereas steps 7 and 10 require the input of ADP, each yielding ATP. [7] The enzymes necessary to break down glucose are found in the cytoplasm , the viscous fluid that fills living cells, where the glycolytic reactions take place.
The systematic name of this enzyme class is ATP:3-dephospho-CoA 5"-triphosphoribosyltransferase. Other names in common use include 2'-(5"-triphosphoribosyl)-3-dephospho-CoA synthase , ATP:dephospho-CoA 5-triphosphoribosyl transferase , and CitG .
2 o → [ro-po 3] 2− + [ho 3 p-o-po 3] 3− + h + At cytoplasmic conditions, where the ADP/ATP ratio is 10 orders of magnitude from equilibrium, the Δ G is around −57 kJ/mol. [ 12 ] Along with pH, the free energy change of ATP hydrolysis is also associated with Mg 2+ concentration, from ΔG°' = −35.7 kJ/mol at a Mg 2+ concentration of ...