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Reed–Sternberg cells are CD30 and CD15 positive except in the lymphocyte predominance type where they are negative, but are usually positive for CD20 and CD45. The presence of these cells is necessary in the diagnosis of Hodgkin lymphoma – the absence of Reed–Sternberg cells has very high negative predictive value.
Hodgkin lymphoma (HL) is a type of lymphoma in which cancer originates from a specific type of white blood cell called lymphocytes, where multinucleated Reed–Sternberg cells (RS cells) are present in the patient's lymph nodes.
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a slow-growing CD20 positive form of Hodgkin lymphoma, a cancer of the immune system's B cells. [ 1 ] [ 2 ] NLPHL is an uncommon sub-type of Hodgkin lymphoma, making up 5-10% of Hodgkin lymphomas. [ 3 ]
The five-year survival rate in the United States for all Hodgkin lymphoma subtypes is 85%, [4] while that for non-Hodgkin lymphomas is 69%. [15] Worldwide, lymphomas developed in 566,000 people in 2012 and caused 305,000 deaths. [16] They make up 3–4% of all cancers, making them as a group the seventh-most-common form.
It is composed of large tumor nodules with lacunar Reed–Sternberg cell (RS cells) surrounded by fibrotic collagen bands. [ citation needed ] The British National Lymphoma Investigation further categorized NSHL based upon Reed–Sternberg cells into "nodular sclerosis type I" (NS I) and "nodular sclerosis type II" (NS II), with the first ...
943 21941 Ensembl ENSG00000120949 ENSMUSG00000028602 UniProt P28908 Q60846 RefSeq (mRNA) NM_001243 NM_001281430 NM_152942 NM_009401 RefSeq (protein) NP_001234 NP_001268359 NP_033427 Location (UCSC) Chr 1: 12.06 – 12.14 Mb Chr 4: 144.99 – 145.04 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CD30, also known as TNFRSF8 (TNF receptor superfamily member 8), is a cell membrane ...
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