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Estrogen dosages for prostate cancer; Route/form Estrogen Dosage Ref(s) Oral: Estradiol: 1–2 mg 3x/day [1] Conjugated estrogens: 1.25–2.5 mg 3x/day [2] [3] Ethinylestradiol: 0.15–3 mg/day [2] [3] [4] Ethinylestradiol sulfonate: 1–2 mg 1x/week [5] [3] [6] Diethylstilbestrol: 1–3 mg/day [2] [7] Dienestrol: 5 mg/day [8] Hexestrol: 5 mg ...
High-dose estrogen therapy is used in the treatment of prostate cancer. [52] Estrogens that have been used include diethylstilbestrol , fosfestrol , ethinylestradiol , ethinylestradiol sulfonate , polyestradiol phosphate , and estradiol undecylate , as well as the dual estrogenic and cytostatic agent estramustine phosphate .
Polyestradiol phosphate (PEP), sold under the brand name Estradurin, is an estrogen medication which is used primarily in the treatment of prostate cancer in men. [1] [9] [2] [10] It is also used in women to treat breast cancer, as a component of hormone therapy to treat low estrogen levels and menopausal symptoms, and as a component of feminizing hormone therapy for transgender women.
A study that used high- to very-high-dose oral estradiol to treat postmenopausal women with estrogen receptor-positive breast cancer found that mean steady-state estradiol levels in the 6 mg/day group were about 300 pg/mL and in the 30 mg/day group were about 2,400 pg/mL. [37]
[17] [5] [1] [10] The medication is usually reserved for use in hormone-refractory cases of prostate cancer, although it has been used as a first-line monotherapy as well. [3] Response rates with EMP in prostate cancer are said to be equivalent to conventional high-dose estrogen therapy. [18]
Estradiol undecylate has been used as a form of high-dose estrogen therapy to treat prostate cancer, but has since largely been superseded for this indication by newer agents with fewer adverse effects (e.g., gynecomastia and cardiovascular complications) like GnRH analogues and nonsteroidal antiandrogens.