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Pimobendan is indicated for the management of the signs of mild, moderate, or severe congestive heart failure in dogs due to clinical myxomatous mitral valve disease (MMVD) or dilated cardiomyopathy (DCM); [1] [7] and for use with concurrent therapy for congestive heart failure (e.g.,furosemide, etc.) as appropriate on a case-by-case basis. [1]
Mitral valve replacement is a procedure whereby the diseased mitral valve of a patient's heart is replaced by either a mechanical or tissue (bioprosthetic) valve. The mitral valve may need to be replaced because: [1] The valve is leaky (mitral valve regurgitation) The valve is narrowed and doesn't open properly (mitral valve stenosis)
Older, small breeds of dogs are prone to congestive heart failure due to degeneration of the mitral valve. This condition is known to be inherited in Cavalier King Charles Spaniels. Degenerative valve disease is the most common form of heart disease in dogs. [25]
Braunwald designed and fabricated an experimental, artificial mitral valve prostheses, implanting them in dogs at the National Heart Institute's surgical clinic in 1959. On March 11, 1960, she performed the first successful human implant, in a 44-year-old woman with mitral regurgitation .
The entire surgery lasts five hours, during which time the dog is connected to a blood oxygenator and the heart is bypassed. The defective heart valve is removed and the replacement valve, typically from bovine pericardium, is precisely sewn into place. The dog’s heart is then restarted and monitored for at least two hours after the surgery ...
Heart valve dysplasia (including mitral and tricuspid valve dysplasia) is a congenital heart abnormality in dogs. Dysplasia of the mitral and tricuspid valves - also known as the atrioventricular (AV) valves - can appear as thickened, shortened, or notched valves. Chordae tendineae are also usually abnormal. [49]
In 1968, he collaborated with American engineer Donald Shiley to develop the Björk–Shiley valve, a mechanical prosthetic heart valve. It was the first "tilting disc valve", used to replace the aortic or mitral valve. Many modifications followed, including the convexo-concave valve. The convexo-concave valve had defects in form of strut ...
Mitral valve repair is mainly used to treat stenosis (narrowing) or regurgitation (leakage) of the mitral valve. [citation needed] A mitral balloon valvuloplasty enlarges the valve opening to allow greater oxygenated blood flow into the left ventricle, and since severe mitral regurgitation can be a major complication, degrees of stenosis, regurgitation, and valve anatomical features are taken ...