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Clinical studies were conducted under an Investigational New Drug Application; clomifene was third drug for which an IND had been filed under the 1962 Kefauver Harris Amendment to the Federal Food, Drug, and Cosmetic Act that had been passed in response to the thalidomide tragedy. [10] It was approved for marketing in 1967 under the brand name ...
Collabora Online Draw and Writer – Enterprise-ready edition of LibreOffice accessible from a web browser. The Draw application is for flyers, newsletters, brochures and more, Writer has most of the functionality too. [4] Scribus – Designed for layout, typesetting, and preparation of files for professional-quality image-setting equipment. It ...
Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms of life. [1] [2] The acronym serpin was originally coined because the first serpins to be identified act on chymotrypsin-like serine proteases (serine protease inhibitors).
Most syntheses of benzothiophene create substituted benzothiophenes as a precursor to further reactions. An example is the reaction of an alkyne-substituted 2-bromobenzene with either sodium sulfide or potassium sulfide to form benzothiophene with an alkyl substitution at position 2.
Some jurisdictions use free voluntary or mandatory treatment programs for frequent known users. Simple possession can carry long prison terms in some countries, particularly in East Asia, where the sale of cannabis may lead to a sentence of life in prison or even execution.
Finally, on August 6, 2013, the Hulu application became available in Japan and on October 17, 2013, the Hulu Plus application was launched in North America, along with a one-week free trial. [188] [189] On November 29, 2013, the YouTube application was released for the Nintendo 3DS in Europe and North America. [190] It was discontinued in ...