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Furthermore, should DMARDs fail, tocilizumab can be used for tumor necrosis factor (TNF) inhibitor treatments in NICE guidance. [9] Combinations of DMARDs are often used, because each drug in the combination can be used in a smaller dose than if it were given alone, thus reducing the risk of side effects. [citation needed]
A fasting blood sugar level of ≥ 7.0 mmol / L (126 mg/dL) is used in the general diagnosis of diabetes. [17] There are no clear guidelines for the diagnosis of LADA, but the criteria often used are that the patient should develop the disease in adulthood, not need insulin treatment for the first 6 months after diagnosis and have autoantibodies in the blood.
The dose-limiting side effects are liver damage, lung disease and immunosuppression. [27] The most common side effects (occurring in >1% of those treated with it) are, in approximately descending order of frequency: [7] [10] [2] [28] [29] [5] [4] diarrhea, respiratory tract infections, hair loss, high blood pressure, rash, nausea, bronchitis, headache, abdominal pain, abnormal liver function ...
In the early days of insulin treatment for type 1 diabetes there was much debate as to whether strict control of hyperglycaemia would delay or prevent the long-term complications of diabetes. The work of Pirart [50] suggested that microvascular complications of diabetes were less likely to occur in individuals with better glycaemic control.
Dosage changes can help address that, at the risk of side effects and complications. [108] Women with type 1 diabetes show a higher than normal rate of polycystic ovarian syndrome (PCOS). [110] The reason may be that the ovaries are exposed to high insulin concentrations since women with type 1 diabetes can have frequent hyperglycemia. [111]
Type 1 diabetes is a disease caused by the lack of insulin. Thus, insulin is the main treatment agent for type 1 and is typically administered via subcutaneous injection. Type 2 diabetes is a disease of insulin resistance by cells. Type 2 diabetes is the most common type of diabetes.
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