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Antiretroviral drugs are used to manage HIV/AIDS. Multiple antiretroviral drugs are often combined into a single pill in order to reduce pill burden . Some of these combinations are complete single-tablet regimens; the others must be combined with additional pills to make a treatment regimen.
In April 1995, Merck and the National Institute of Allergy and Infectious Diseases began recruiting patients for a trial examining the effects of a three drug combination of the protease inhibitor indinavir and two nucleoside analogs, [27] illustrating the substantial benefit of combining two NRTIs with a new class of antiretrovirals, protease ...
Raltegravir (Isentress), developed by Merck & Co., was the first INSTI approved by the FDA in October 2007.; Elvitegravir (Vitekta), licensed by Gilead Sciences from Japan Tobacco, was approved by the U.S. Food and Drug Administration in August 2012, for use in adults starting HIV treatment for the first time as part of the fixed dose combination with emtricitabine and tenofovir disoproxil ...
AZT has been used for post-exposure prophylaxis (PEP) in combination with another antiretroviral drug called lamivudine. Together they work to substantially reduce the risk of HIV infection following the first single exposure to the virus. [14] More recently, AZT has been replaced by other antiretrovirals such as tenofovir to provide PEP. [15]
Lamivudine/zidovudine, sold under the brand name Combivir among others, is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. [2] It contains two antiretroviral medications , lamivudine and zidovudine . [ 2 ]
Patients are advised to discuss any history of bone issues, kidney issues, or hepatitis B infection with their healthcare provider. [19] Effectiveness of PrEP for prevention of infection is reliant on an individual's ability to take the medication consistently. [20] Emtricitabine/tenofovir is also used for HIV post-exposure prophylaxis. People ...
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