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One side of the tether is bound to the ion channel protein and the other end of the tether is bound to a blocking group, which has a high binding affinity for an exposed portion of the pore. When the tether is lengthened, it allows the blocking section to bind to the pore and prevent ionic current.
Developmental bioelectricity is a sub-discipline of biology, related to, but distinct from, neurophysiology and bioelectromagnetics. Developmental bioelectricity refers to the endogenous ion fluxes, transmembrane and transepithelial voltage gradients, and electric currents and fields produced and sustained in living cells and tissues.
The first voltage sensitive phosphatase was discovered as a result of a genome-wide search in the sea squirt Ciona intestinalis. [1] The search was designed to identify proteins which contained a sequence of amino acids called a voltage sensor, because this sequence of amino acids confers voltage sensitivity to voltage-gated ion channels.
The Tree of Life: A multi-authored, distributed Internet project containing information about phylogeny and biodiversity. MIT video lecture series on biology; A wiki site for protocol sharing run from MIT. Biology and Bioethics. Biology online wiki dictionary. Biology Video Sharing Community.
The GUS reporter system (GUS: β-glucuronidase) is a reporter gene system, particularly useful in plant molecular biology [1] and microbiology. [2] Several kinds of GUS reporter gene assay are available, depending on the substrate used. The term GUS staining refers to the most common of these, a histochemical technique.
A GEVI can be evaluated by its many characteristics. These traits can be classified into two categories: performance and compatibility. The performance properties include brightness, photostability, sensitivity, kinetics (speed), linearity of response, etc., while the compatibility properties cover toxicity (phototoxicity), plasma membrane localization, adaptability of deep-tissue imaging, etc ...
Sources of information are commonly categorized as primary, secondary, or tertiary sources.In brief, a primary source is one close to the event with firsthand knowledge (for example, an eyewitness); a secondary source is at least one step removed (for example, a book about an event written by someone not involved in it); and a tertiary source is an encyclopaedia or textbook that provides a ...
Loss, misuse, modification, or unauthorized access to sensitive information can adversely affect the privacy or welfare of an individual, trade secrets of a business or even the security and international relations of a nation depending on the level of sensitivity and nature of the information. [2]