Search results
Results From The WOW.Com Content Network
Cytarabine-5´-triphosphate is a substrate for SAMHD1. [18] Furthermore, SAMHD1 has been shown to limit the efficacy of cytarabine efficacy in patients. [19] When used as an antiviral, cytarabine-5´-triphosphate functions by inhibiting viral DNA synthesis. [20]
Arabinofuranosylcytosine triphosphate is a nucleotide that inhibits the synthesis of DNA by acting as an antimetabolic agent against deoxycytidine (a component of DNA). It is the biologically active form of cytarabine. [1]
Cytarabine (Cytosine arabinoside) Gemcitabine; ... Pyrimidine antimetabolites are commonly used to treat cancer by interfering with DNA replication. [1 ...
Antimetabolites generally impair DNA replication machinery, either by incorporation of chemically altered nucleotides or by depleting the supply of deoxynucleotides needed for DNA replication and cell proliferation. Examples of cancer drug antimetabolites include, but are not limited to the following: 5-Fluorouracil (5-FU) 6-Mercaptopurine (6-MP)
There is a large family of nucleoside analogue reverse transcriptase inhibitors, because DNA production by reverse transcriptase is very different from normal human DNA replication, so it is possible to design nucleoside analogues that are preferentially incorporated by the former. Some nucleoside analogues, however, can function both as NRTIs ...
[4] [6] It contains the liposomal bound daunorubicin, an anthracycline topoisomerase inhibitor, and cytarabine, a nucleoside metabolic inhibitor. [ 4 ] Medical uses
A hypomethylating agent (or demethylating agent [1]) is a drug that inhibits DNA methylation: the modification of DNA nucleotides by addition of a methyl group.Because DNA methylation affects cellular function through successive generations of cells without changing the underlying DNA sequence, treatment with a hypomethylating agent is considered a type of epigenetic therapy.
This is the active form of vidarabine and is both an inhibitor and a substrate of viral DNA polymerase. [7] When used as a substrate for viral DNA polymerase, ara-ATP competitively inhibits dATP leading to the formation of ‘faulty’ DNA. This is where ara-ATP is incorporated into the DNA strand replacing many of the adenosine bases.