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Geriatric dogs treated with selegiline show improvements in sleeping pattern, reduced urinary incontinence, and increased activity level, with most showing improvements by one month of treatment. [303] [304] Though it is labeled for use in dogs only, selegiline has been used off-label for geriatric cats with cognitive dysfunction. [305]
Canine cognitive dysfunction (CCD) is a disease prevalent in dogs that exhibit symptoms of dementia or Alzheimer's disease shown in humans. [1] CCD creates pathological changes in the brain that slow the mental functioning of dogs resulting in loss of memory, motor function, and learned behaviors from training early in life.
Selegiline is thought to exert its therapeutic effects in the treatment of the motor symptoms of Parkinson's disease by increasing dopamine levels in the substantia nigra pars compacta (SNpc) of the basal ganglia, which projects to the caudate nucleus and putamen of the striatum, thereby enhancing the signaling of the nigrostriatal pathway.
The AKC reports that one study found that 28% of dogs between 11 and 12 years of age have at least one sign of dog dementia, and that increased to 68% in dogs over 15 years of age.
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS) and are implicated in many neurological processes, including motivational and incentive salience, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling.
Pages in category "Selegiline" The following 8 pages are in this category, out of 8 total. This list may not reflect recent changes. D. Deprenyl; Desmethylselegiline; K.