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Caffeine keeps you awake by blocking adenosine receptors. Each type of adenosine receptor has different functions, although with some overlap. [3] For instance, both A 1 receptors and A 2A play roles in the heart, regulating myocardial oxygen consumption and coronary blood flow, while the A 2A receptor also has broader anti-inflammatory effects throughout the body. [4]
A 1 receptors are implicated in sleep promotion by inhibiting wake-promoting cholinergic neurons in the basal forebrain. [6] A 1 receptors are also present in smooth muscle throughout the vascular system. [7] The adenosine A 1 receptor has been found to be ubiquitous throughout the entire body. [citation needed]
These receptors enable the regulation of multiple processes such as cell proliferation, differentiation, function, and death. [47] The activation of the adenosine A1 receptor is required for osteoclast differentiation and function, whereas the activation of the adenosine A2A receptor inhibits osteoclast function. The other three adenosine ...
The A 1 receptors couple to G i/o and decrease cAMP levels, while the A 2 adenosine receptors couple to G s, which stimulates adenylate cyclase activity. In addition, A 1 receptors couple to G o , which has been reported to mediate adenosine inhibition of Ca 2+ conductance, whereas A 2B and A 3 receptors also couple to G q and stimulate ...
The actions of the A 2A receptor are complicated by the fact that a variety of functional heteromers composed of a mixture of A 2A subunits with subunits from other unrelated G-protein coupled receptors have been found in the brain, adding a further degree of complexity to the role of adenosine in modulation of neuronal activity.
Print/export Download as PDF; Printable version; In other projects ... Pages in category "Adenosine receptors" The following 5 pages are in this category, out of 5 ...
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord.The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all parts of the bodies of bilaterally symmetric and triploblastic animals—that is, all multicellular animals except sponges and diploblasts.
Neurotransmitter receptor – membrane receptor that can be activated by a neurotransmitter. Interactions between neurotransmitters and neurotransmitter receptors can evoke a wide range of differing responses from the cell receiving the signal, including excitation, inhibition, and various types of modulation. Category:Receptors