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Myelopathy describes any neurologic deficit related to the spinal cord. [1] The most common form of myelopathy in humans, cervical spondylotic myelopathy (CSM) , [ 2 ] [ 3 ] also called degenerative cervical myelopathy , [ 4 ] results from narrowing of the spinal canal ( spinal stenosis ) ultimately causing compression of the spinal cord. [ 5 ]
In medicine, myopathy is a disease of the muscle [1] in which the muscle fibers do not function properly. Myopathy means muscle disease ( Greek : myo- muscle + patheia -pathy : suffering ). This meaning implies that the primary defect is within the muscle, as opposed to the nerves (" neuropathies " or " neurogenic " disorders) or elsewhere (e.g ...
Common types of myopathy due to statins include myalgia, myositis, and rhabdomyolysis. Statins induce myopathy by inhibiting protein synthesis within the muscle. [6] Statin therapy tends to not show any histopathological differences, and thus a biopsy does not reveal too much about the damage. Often, the damage is found within the mitochondria.
Vascular myelopathy (vascular disease of the spinal cord) refers to an abnormality of the spinal cord in regard to its blood supply. [1] The blood supply is complicated and supplied by two major vessel groups: the posterior spinal arteries and the anterior spinal arteries —of which the Artery of Adamkiewicz is the largest. [ 2 ]
[4] [5] The "M" in hIBM is an abbreviation for "myopathy" while the "M" in IBM is for "myositis". [6] In IBM, two processes appear to occur in the muscles in parallel, one autoimmune and the other degenerative. Inflammation is evident from the invasion of muscle fibers by immune cells.
With critical illness myopathy, no other cause of the muscle degeneration can be found. [ citation needed ] Unlike Guillain–Barre syndrome , another neurological disorder that causes weakness, patients with critical illness polyneuropathy do not have loss of the myelin sheath that normally surrounds neurons ( demyelination ).
Statin-associated autoimmune myopathy (SAAM), also known as anti-HMGCR myopathy, is a very rare form of muscle damage caused by the immune system in people who take statin medications. [1] However, there are cases of SAAM in patients who have not taken statin medication, and this can be explained by the exposure to natural sources of statin ...
Childhood-onset DM1 is defined as onset of symptoms between ages 1 and 10 years. [5] ... Type 2 (DM2), also known as proximal myotonic myopathy (PROMM), is rarer and ...