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The machine was tested in clinical studies for the treatment of a broad range of medical conditions related to Intravascular Volume Status, such as anemia, [4] congestive heart failure, [5] sepsis, [6] CFS, [7] Hyponatremia, [8] Syncope [9] and more.
Hypoosmolar hyponatremia is a condition where hyponatremia is associated with a low plasma osmolality. [1] The term "hypotonic hyponatremia" is also sometimes used. [2] When the plasma osmolarity is low, the extracellular fluid volume status may be in one of three states: low volume, normal volume, or high volume.
[2] [9] Mild symptoms include a decreased ability to think, headaches, nausea, and poor balance. [1] [3] Severe symptoms include confusion, seizures, and coma; [1] [2] [9] death can ensue. [10] The causes of hyponatremia are typically classified by a person's body fluid status into low volume, normal volume, or high volume. [4]
In an adrenal crisis, hypotension occurs due to low cortisol and volume depletion. [9] Hypovolemia might be resistant to vasopressors and fluids if it is not identified. In secondary adrenal insufficiency, hyponatremia results from decreased kidney excretion of electrolyte-free water and the inability to suppress vasopressin . [ 5 ]
[2] Moderate or severe hyponatremia, or hyponatremia with severe symptoms is treated by raising the serum sodium level by 1–2 mmol per liter per hour for the first few hours with a goal of raising levels less than 8–10 mmol per liter in the first 24 hours and 18 mmol per liter in the first 48 hours. [2]
Hypovolemic shock is a form of shock caused by severe hypovolemia (insufficient blood volume or extracellular fluid in the body). [1] [2] It can be caused by severe dehydration or blood loss. [3] [2] Hypovolemic shock is a medical emergency; if left untreated, the insufficient blood flow can cause damage to organs, leading to multiple organ ...
The signs and symptoms of hypovolemia are primarily due to the consequences of decreased circulating volume and a subsequent reduction in the amount of blood reaching the tissues of the body. [9] In order to properly perform their functions, tissues require the oxygen transported in the blood. [10]
Isotonic hyponatremia is a form of hyponatremia with mOsm measured between 280 and 295. It can be associated with pseudohyponatremia, or with isotonic infusion of glucose or mannitol . [ 1 ]