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While DNA damage happens frequently and naturally in the cell from endogenous sources, clustered damage is a unique effect of radiation exposure. [41] Clustered damage takes longer to repair than isolated breakages, and is less likely to be repaired at all. [42] Larger radiation doses are more prone to cause tighter clustering of damage, and ...
Exposure to radiation causes chemical changes in gases. The least susceptible to damage are noble gases, where the major concern is the nuclear transmutation with follow-up chemical reactions of the nuclear reaction products. High-intensity ionizing radiation in air can produce a visible ionized air glow of telltale
Damage from oxygen radicals, inflammatory cells and molecules, edema, and other mechanisms mean that when oxygen flow is restored to the tissue, it can cause further damage to the kidney, potentially worsening prognosis. Despite this risk, the return of blood flow to the tissue is necessary for its survival, so clinical strategies focus on ...
The effects of RILP can be debilitating. With no effective treatment to control radiation damage's progressive nature, limb dysfunction is the likely result. [10] Radiation damage's outcome is related to its initial onset time. Acute symptoms, occurring in the first few days, have the most favorable outcomes, likely diminishing within a few ...
Contrast-induced nephropathy (CIN) is a purported form of kidney damage in which there has been recent exposure to medical imaging contrast material without another clear cause for the acute kidney injury. Despite extensive speculation, the actual occurrence of contrast-induced nephropathy has not been demonstrated in the literature. [1]
Radiation poisoning, also called "radiation sickness" or a "creeping dose", is a form of damage to organ tissue due to excessive exposure to ionizing radiation. The term is generally used to refer to acute problems caused by a large dosage of radiation in a short period, though this also has occurred with long-term exposure to low-level radiation.
Renal cortical necrosis (RCN) is a rare cause of acute kidney failure.The condition is "usually caused by significantly diminished arterial perfusion of the kidneys due to spasms of the feeding arteries, microvascular injury, or disseminated intravascular coagulation" and is the pathological progression of acute tubular necrosis. [1]
Diabetes mellitus; diabetes is a known cause of microvascular disease, which similar to smoking, can worsen the blood supply and perfusion to tissues affected by radiation. [7] Dental disease and extractions; patients with poor oral hygiene and dental disease prior to radiation, including edentulous patients and those with dentures, are more ...