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Biopsy: Granulomatous inflammation within the arterial wall or in the perivascular area Sclerokeratitis associated with GPA According to the Chapel Hill Consensus Conference (CHCC) on the nomenclature of systemic vasculitis (1992), establishing the diagnosis of GPA demands [ 22 ] a granulomatous inflammation involving the respiratory tract, and ...
Granulomatous mediastinitis is due to a granulomatous process of the mediastinal lymph nodes leading to fibrosis and chronic abscesses in the mediastinum. The most common causes are histoplasmosis and tuberculosis infections. Non-granulomatous fibrosing mediastinitis is caused by an idiopathic reaction to drugs and radiation therapy. [6]
The diagnosis requires consistent symptoms with two additional signs: [citation needed] Chest X-ray or CT scan showing evidence of right middle lobe (or left lingular lobe) lung infection; Sputum culture or bronchoalveolar lavage culture demonstrating the infection is caused by MAC; Disseminated MAC is most readily diagnosed by one positive ...
The most common benign coin lesion is a granuloma (inflammatory nodule), for example due to tuberculosis or a fungal infection, such as Coccidioidomycosis. [6] Other infectious causes include a lung abscess, pneumonia (including pneumocystis pneumonia) or rarely nocardial infection or worm infection (such as dirofilariasis or dog heartworm ...
Eosinophilic granulomatosis with polyangiitis consists of three stages, but not all patients develop all three stages or progress from one stage to the next in the same order; [7] whereas some patients may develop severe or life-threatening complications such as gastrointestinal involvement and heart disease, some patients are only mildly affected, e.g. with skin lesions and nasal polyps. [8]
The signs and symptoms depend on the organ involved. [2] Often, no symptoms or only mild symptoms are seen. [2] When it affects the lungs, wheezing, coughing, shortness of breath, or chest pain may occur. [3] Some may have Löfgren syndrome with fever, enlarged hilar lymph nodes, arthritis, and a rash known as erythema nodosum. [2]
Chronic granulomatous disease (CGD), also known as Bridges–Good syndrome, chronic granulomatous disorder, and Quie syndrome, [1] is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly the superoxide radical due to defective phagocyte NADPH oxidase) used to kill certain ingested pathogens. [2]
Granulomatous–lymphocytic interstitial lung disease (GLILD) is a lung complication of common variable immunodeficiency disorders (CVID). It is seen in approximately 15% of patients with CVID. [ 1 ] It has been defined histologically as the presence of (non-caseating) granuloma and lymphoproliferation in the lung. [ 1 ]