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Daptomycin, sold under the brand name Cubicin among others, is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms. [ 4 ] Daptomycin was removed from the World Health Organization's List of Essential Medicines in 2019.
Pulmonary toxicity is the medical name for side effects on the lungs. Although most cases of pulmonary toxicity in medicine are due to side effects of medicinal drugs, many cases can be due to side effects of radiation (radiotherapy). Other (non-medical) causes of pulmonary toxicity can be chemical compounds and airborne particulate matter.
In the early 20th century, the German chemist Paul Ehrlich was developing theories of selective toxicity based largely on the ability of certain dyes to kill microbes. Gerhard Domagk , who would later win a Nobel Prize for his efforts, made a major breakthrough in 1932 with the discovery of the antibacterial prontosil red (sulfonamidochrysoidine).
Daptomycin: Cubicin: Gram-positive organisms, but is inhibited by pulmonary surfactant so less effective against pneumonias: Binds to the membrane and cause rapid depolarization, resulting in a loss of membrane potential leading to inhibition of protein, DNA and RNA synthesis. Macrolides(Bs) Azithromycin: Zithromax, Sumamed, Xithrone
“Someone would have to have a lung disease. It’s almost unreported because it’s so rare.” Researchers have found that the far more common overdose risk with Suboxone occurs when an addict shoots up the drug intravenously in combination with a respiratory depressant, such as a benzodiazepine like Xanax.
Diffuse alveolar damage (DAD): an acute lung condition with the presence of hyaline membranes. [2] These hyaline membranes are made up of dead cells, surfactant , and proteins. [ 1 ] The hyaline membranes deposit along the walls of the alveoli, where gas exchange typically occurs, thereby making gas exchange difficult.
disease.2 Children’s lung functioning is not yet fully developed.3–5 Compared to adults, they breathe in greater levels of polluted air relative to their weight and spend more time outside when air pollution levels are the highest.5 And becauseof differences in metabolism,mouthing behavior—such as the tendency to put their
Vitamin D toxicity is typically caused by taking high doses of the vitamin in supplement form, not from food or sunlight, Zumpano adds. If you experience side effects, stop taking vitamin D and ...