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The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 1 ]
In addition to evidence suggesting that inflammation is not sufficient for the development of major depression, evidence for a lack of complete overlap also comes from findings that depression often occurs without existing immune challenges, with social adversity appearing to cause depression without the requirement of underlying inflammation.
It is difficult to develop an animal model that perfectly reproduces the symptoms of depression in patients. It is generic that 3 standards may be used to evaluate the reliability of an animal version of depression: the phenomenological or morphological appearances (face validity), a comparable etiology (assemble validity), and healing similarities (predictive validity).
In physiology and medicine, depression [1] refers to a lowering, in particular a reduction in a specific biological variable or the functions of an organ. It is the opposite of elevation. For example, it is possible to refer to "depressed thyroid function" or to a depression of blood flow in a particular area. Further examples:
Physiological hyperarousal is defined by increased activity in the sympathetic nervous system, in response to threat. [11] Physiological hyperarousal is unique to anxiety disorders. [ 2 ] [ 12 ] Some symptoms of physiological hyperarousal include: shortness of breath, feeling dizzy or lightheaded, dry mouth, trembling or shaking, and sweaty palms.
This article needs to be updated. The reason given is: Many outdated sources and information (older than five years). Please help update this article to reflect recent events or newly available information. (July 2024) Medical condition Major depressive disorder Other names Clinical depression, major depression, unipolar depression, unipolar disorder, recurrent depression Specialty Psychiatry ...
One way depression increases the individual's focus on a problem is by inducing rumination. Depression activates the left ventrolateral prefrontal cortex, which increases attention control and maintains problem-related information in an "active, accessible state" referred to as "working memory", or WM. As a result, depressed individuals have ...
Depression is a mental state of low mood and aversion to activity. [3] It affects about 3.5% of the global population, or about 280 million people worldwide, as of 2020. [4] Depression affects a person's thoughts, behavior, feelings, and sense of well-being. [5]