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Depression can have multiple, sometimes overlapping, origins. Depression can be a symptom of some mood disorders, some of which are also commonly called depression, such as major depressive disorder, bipolar disorder and dysthymia. [7] Additionally, depression can be a normal temporary reaction to life events, such as the loss of a loved one.
Depressed mood is the most common symptom of a major depressive episode. [3] Either a depressive mood or a loss of interest or pleasure in everyday activities for most of the day or every day must be present for a diagnosis of a major depressive episode. [1]
Such illness responses include lethargy, depression, anxiety, malaise, loss of appetite, [3] [4] sleepiness, [5] hyperalgesia, [6] reduction in grooming [1] [7] and failure to concentrate. [8] Sickness behavior is a motivational state that reorganizes the organism's priorities to cope with infectious pathogens .
While major depression is associated with increased inflammasome activation in general, the NLRP3 inflammasome complex has received the most attention in relation to major depression due to both its role in triggering the release of interleukin-1β and interleukin-18 and its association with depression and depression-like symptoms in both ...
The painting Stańczyk, which contains a depiction of the sad clown paradox. The sad clown paradox is the contradictory association, in performers, between comedy and mental disorders such as depression and anxiety.
Spannagel notes that if you’re feeling dread most of the time, or the feelings are especially intense, or you’ve felt this way for longer than a few days, you should seek clinical help to rule ...
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