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Zidovudine (ZDV), also known as azidothymidine (AZT), was the first antiretroviral medication used to prevent and treat HIV/AIDS. It is generally recommended for use in combination with other antiretrovirals. [6] It may be used to prevent mother-to-child spread during birth or after a needlestick injury or other potential exposure. [6]
Lamividine/zidovudine is categorized pregnancy category C in the United States, meaning there are potential risks to the baby during pregnancy, but potential benefits may outweigh the risks. [7] Data supports the safety of this combination during pregnancy and is often preferred over other fixed dose combinations during pregnancy. [8]
zidovudine (AZT or ZDV) It is indicated in the treatment of AIDS/HIV -1. [ 2 ] For this purpose, the combination is very useful in pregnant women to decrease the risk of mother-to-child transmission .
This compound had been prepared in 1964 as a potential anti-cancer agent but was shown to be ineffective. [15] In 1974 zidovudine was reported to have activity against retroviruses and was subsequently re-screened as an antiviral when the AIDS epidemic hit Western societies during the mid-1980s.
Because of the complexity of selecting and following a regimen, the potential for side effects, and the importance of taking medications regularly to prevent viral resistance, such organizations emphasize the importance of involving patients in therapy choices and recommend analyzing the risks and the potential benefits. [7]
Protease inhibitors (PIs) are medications that act by interfering with enzymes that cleave proteins.Some of the most well known are antiviral drugs widely used to treat HIV/AIDS, hepatitis C and COVID-19.
A new review reports that nine people taking semaglutide and tirzepatide — the active ingredient in GLP-1 medications — experienced vision issues, including three potentially blinding eye ...
zidovudine: September 26, 1997 ViiV Healthcare: No Kaletra (developed countries) Aluvia (developing countries) lopinavir: ritonavir: September 15, 2000 Abbott Laboratories: No Trizivir: abacavir lamivudine zidovudine November 15, 2000 ViiV Healthcare Yes Epzicom Kivexa (EU, RU) abacavir lamivudine August 2, 2004 ViiV Healthcare No Generics, e.g ...