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Description: Side effects of spironolactone (25–400 mg/day) with ≥1% incidence in a 2017 hybrid systematic review of clinical studies of spironolactone for acne in women. Side effects with <1% incidence included postural hypotension, depression, diarrhea, muscle pain, increased appetite, drowsiness, rashes/drug eruptions, chloasma-like skin ...
Description: Side effects of spironolactone (25–400 mg/day) with ≥1% incidence in a 2017 hybrid systematic review of clinical studies of spironolactone for acne in women. Side effects with <1% incidence included postural hypotension, depression, diarrhea, muscle pain, increased appetite, drowsiness, rashes/drug eruptions, chloasma-like skin ...
A 2017 hybrid systematic review reported that data from 50 studies on androgen levels with spironolactone in women were equivocal. [67] A 1993 review reported that changes in hormone levels with spironolactone were very heterogeneous, with most changes not achieving significance. [16]
One phase 3 clinical trial, published in The BMJ last year, followed 400 women taking either spironolactone or a placebo for 24 weeks. Side effects were slightly more common in women who got the ...
However, spironolactone is metabolized to three active metabolites, which give it prolonged activity (13.8 – 16. 5 hours). Spironolactone has a long half-life and is excreted 47-51% through kidneys. Patients with chronic kidney disease therefore require close monitoring when taking the drug. Spironolactone is also eliminated through feces (35-41%
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Medications like diuretics and antidepressants can increase the blood pressure-lowering effects of minoxidil. However, interactions are more likely with oral minoxidil than topical minoxidil.
By the late 1990s, studies of people using Risperdal and its competitor anti-psychotics had started to reveal that young patients showed an increase in levels of prolactin—a hormone that at its normal levels enables women to produce breast milk. The data seemed to suggest that Risperdal was the worst offender.