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C5 convertase is an enzyme belonging to a family of serine proteases that play key role in the innate immunity. It participates in the complement system ending with cell death. There are four different C5 convertases able to specifically convert the protein C5 to C5a and C5b fragments.
From C4–5, the thyroid cartilage [10] From C6–7, the cricoid cartilage [10] At C6, the oesophagus becomes continuous with the laryngopharynx and also where the larynx becomes continuous with the trachea. It is also the level where the carotid pulse can be palpated against the transverse process of the C6 vertebrae.
C5 convertase then cleaves C5 into C5a and C5b. [3] Like C3a, C5a is also an anaphylatoxin that interacts with its cognate C5a receptor (C5aR) to attract leukocytes. [ 1 ] Subsequent interactions between C5b and other terminal components C6, C7, C8, and C9 form the membrane attack complex or the C5b-9 complex which forms pores on the target ...
The thyroid cartilage is found between the levels of the C4 to C5 vertebrae. The oblique line is a line on the thyroid cartilage. It marks the upper lateral borders of the thyroid gland. Two muscles originate along the line, the thyrohyoid muscle and inferior pharyngeal constrictor. The sternothyroid inserts along the line. Thyroid cartilage
The C5-convertase of the alternative pathway consists of (C3b) 2 BbP (sometimes referred to as C3b 2 Bb). After the creation of C5 convertase (either as (C3b) 2 BbP or C4b2a3b from the classical pathway), the complement system follows the same path regardless of the means of activation (alternative, classical, or lectin). C5-convertase cleaves ...
A spotted gar larva at 22 days stained for cartilage (blue) and bone (red). Chondrogenesis is the biological process through which cartilage tissue is formed and developed. . This intricate and tightly regulated cellular differentiation pathway plays a crucial role in skeletal development, as cartilage serves as a fundamental component of the embryonic skele
In other words, the facet joint between C4 and C5 vertebral segments is innervated by the C4 and C5 medial branch nerves. However, there are two exceptions: The facet joint between C2 and C3 is innervated by the third occipital nerve and the C3 medial branch nerve. The facet joint between C7 and T1 is innervated by the C7 and C8 medial branch ...
12266 Ensembl ENSG00000125730 ENSMUSG00000024164 UniProt P01024 P01027 RefSeq (mRNA) NM_000064 NM_009778 RefSeq (protein) NP_000055 NP_033908 Location (UCSC) Chr 19: 6.68 – 6.73 Mb Chr 17: 57.51 – 57.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It plays a ...