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[4] [3] As such, testosterone cypionate and testosterone enanthate are considered to be "functionally interchangeable" as medications. [4] For reference, testosterone enanthate has an elimination half-life of 4.5 days and a mean residence time of 8.5 days and requires frequent administration of approximately once per week. [21]
The elimination half-life of testosterone varies depending on the route of administration and formulation and on whether or not it is esterified. [8] The elimination half-life of testosterone in the blood or by intravenous injection is only about 10 minutes.
Testosterone esters were synthesized for the first time in 1936, and were found to have greatly improved potency relative to testosterone. [12] Among the esters synthesized, testosterone propionate was the most potent, and for this reason, was selected for further development, subsequently being marketed. [ 12 ]
Testosterone cypionate and testosterone enanthate were formerly available in combination with estradiol cypionate and estradiol valerate, respectively, under the brand names Depo-Testadiol and Ditate-DS, respectively, as oil solutions for intramuscular injection, but these formulations have been discontinued.
Testosterone cypionate: Injection: 50–400 mg up to every four weeks ... t 1/2 Tooltip Elimination half-life MRT Tooltip Mean residence time; Testosterone undecanoate:
Testosterone undecanoate, an ester of testosterone and one of the most widely used androgen esters.. An androgen or anabolic steroid ester is an ester of an androgen/anabolic steroid (AAS) such as the natural testosterone or dihydrotestosterone (DHT) or the synthetic nandrolone (19-nortestosterone).
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