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Technetium (99m Tc) sestamibi (commonly sestamibi; USP: technetium Tc 99m sestamibi; trade name Cardiolite) is a pharmaceutical agent used in nuclear medicine imaging.The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six (sesta=6) methoxyisobutylisonitrile (MIBI) ligands.
Nuclear medicine myocardial perfusion scan with thallium-201 for the rest images (bottom rows) and Tc-Sestamibi for the stress images (top rows). The nuclear medicine myocardial perfusion scan plays a pivotal role in the non-invasive evaluation of coronary artery disease. The study not only identifies patients with coronary artery disease; it ...
Thallium-201 is synthesized by the neutron activation of stable thallium in a nuclear reactor, [18] [19] or by the 203 Tl(p, 3n) 201 Pb nuclear reaction in cyclotrons, as 201 Pb naturally decays to 201 Tl afterwards. [20] It is a radiopharmaceutical, as it has good imaging characteristics without excessive patient radiation dose.
Scanning is time-consuming, and it is essential that there is no patient movement during the scan time. Movement can cause significant degradation of the reconstructed images, although movement compensation reconstruction techniques can help with this. A highly uneven distribution of radiopharmaceutical also has the potential to cause artifacts.
Gallium scan showing panda (A) and lambda (B) patterns, considered specific for sarcoidosis in the absence of histological confirmation. In the past, the gallium scan was the gold standard for lymphoma staging, until it was replaced by positron emission tomography (PET) using 18 F-fluorodeoxyglucose (FDG).
Scintigraphy (from Latin scintilla, "spark"), also known as a gamma scan, is a diagnostic test in nuclear medicine, where radioisotopes attached to drugs that travel to a specific organ or tissue (radiopharmaceuticals) are taken internally and the emitted gamma radiation is captured by gamma cameras, which are external detectors that form two-dimensional images [1] in a process similar to the ...
Thallium is found in the minerals crookesite TlCu 7 Se 4, hutchinsonite TlPbAs 5 S 9, and lorándite TlAsS 2. [42] Thallium also occurs as a trace element in iron pyrite, and thallium is extracted as a by-product of roasting this mineral for the production of sulfuric acid. [9] [43] Thallium can also be obtained from the smelting of lead and ...
Thallium(III) acetate is the acetate salt of thallium, with the chemical formula Tl(CH 3 COO) 3. As a selective culture medium in microbiology, [1] thallium acetate is toxic, [2] but it can also be used as a hair loss agent. Koremlu, a depilatory that contained the rat poison Thallium acetate was widely marketed during th 1930s.