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Researchers have hypothesized that the syndrome may be due to blood vessel diseases of the kidney, spasms of the kidney vessels, or other bleeding disorders (coagulopathy). The hematuria in LPHS may be due to an abnormal (thick or thin) glomerular basement membrane. The glomerular basement membrane is a tissue in the kidney that filters the blood.
The evaluation of hematuria is dependent upon the visibility of the blood in the urine (i.e. visible/gross vs microscopic hematuria). [6] Visible hematuria must be investigated, as it may be due to a pathological cause. [1] [6] In those with visible hematuria, urological cancer (most frequently bladder or kidney cancer) is discovered in 20–25 ...
Mechanical hemolytic anemia is a form of hemolytic anemia due to mechanically induced damage to red blood cells. Red blood cells, while flexible, may in some circumstances succumb to physical shear and compression. [1] This may result in hemoglobinuria.
In IgA nephropathy, episodes of frank hematuria are more common, and a family history is less common. A kidney biopsy is the only way to diagnose thin basement membrane disease. It reveals thinning of the glomerular basement membrane from the normal 300 to 400 nanometers (nm) to 150 to 250 nm.
The compression causes renal vein hypertension, leading to hematuria (which can lead to anemia) [4] and abdominal pain (classically left flank or pelvic pain). [5] The abdominal pain may improve or worsen depending on positioning. [ 5 ]
“Vitamin D is essential for brain and bone health, and many people are deficient due to limited sun exposure,” says Dr. McQuiston. “Checking your levels with your doctor is a good first step.”
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