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12266 Ensembl ENSG00000125730 ENSMUSG00000024164 UniProt P01024 P01027 RefSeq (mRNA) NM_000064 NM_009778 RefSeq (protein) NP_000055 NP_033908 Location (UCSC) Chr 19: 6.68 – 6.73 Mb Chr 17: 57.51 – 57.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It plays a ...
The cleavage of the C4 results in C4b bearing a thioester functional group [-S-C(O)-]: work in the 1980s on C3, and then on C4, indicated the presence, within the parent C3 and C4 structures, of a unique protein modification, a 15-atom (15-membered) thionolactone ring serving to connect the thiol side chain of the amino acid cysteine (Cys) in a ...
A research division, Seattle Children's Research Institute (SCRI), was established in 2006. [8] In December 2007, Seattle Children's purchased a seven-story building in the Denny Triangle, near downtown Seattle and South Lake Union. [9] With this purchase, Children's acquired nearly 2 square blocks for the research institute. [10]
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A lab test showing ADAMTS13 activity levels of ≤5% is indicative of TTP. [22] Similarly, the gastrointestinal (GI) signs and symptoms of aHUS overlap with those of STEC-HUS. [12] [25] [26] Stool samples from patients with diarrhea or other GI symptoms should be tested for STEC and the presence of Shiga-toxin. However, a positive ...
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