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Hypercalcemia, also spelled hypercalcaemia, is a high calcium (Ca 2+) level in the blood serum. [1] [3] The normal range for total calcium is 2.1–2.6 mmol/L (8.8–10.7 mg/dL, 4.3–5.2 mEq/L), with levels greater than 2.6 mmol/L defined as hypercalcemia.
Maintain calcium and phosphorus levels ... Needed for nerve cells, red blood cells, and to make DNA 6-14 ... 0.9-3.2 × 10 −5 ...
[3] [10] Blood lead levels 50 to 1,000 times higher than preindustrial levels are commonly measured in contemporary human populations around the world. [3] The National Academies evaluated this issue [12] in 1991 and confirmed that the blood lead level of the average person in the US was 300 to 500 times higher than that of pre-industrial humans.
[44] [45] As a result, carbon dioxide levels in the blood decrease and the pH of the blood becomes more alkaline (i.e. the pH is higher and more basic). This causes the maternal kidneys to excrete bicarbonate to compensate for this change in pH. The combined effect of the decreased serum concentrations of both carbon dioxide and bicarbonate ...
(See reference [13] for an illustration of the signaling cascade involving L-type calcium channels in smooth muscle). L-type calcium channels are also enriched in the t-tubules of striated muscle cells, i.e., skeletal and cardiac myofibers. When these cells are depolarized, the L-type calcium channels open as in smooth muscle.
Calcium seen in coronary arteries can provide predictive information beyond that of classical risk factors. [68] High blood levels of the amino acid homocysteine is associated with premature atherosclerosis; [69] whether elevated homocysteine in the normal range is causal is controversial. [70]
However, in many smooth muscle tissues, depolarization is mediated primarily by calcium influx into the cell. L-type calcium channel blockers selectively inhibit these action potentials in smooth muscle which leads to dilation of blood vessels; this in turn corrects hypertension. [10] T-type calcium channel blockers are used to treat epilepsy ...
An L-type calcium channel with its subunits labeled along with some drugs known to inhibit the channel. The L-type calcium channel (also known as the dihydropyridine channel, or DHP channel) is part of the high-voltage activated family of voltage-dependent calcium channel. [2] "L" stands for long-lasting referring to the length of activation.