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Mannitol is a type of sugar alcohol used as a sweetener and medication. [ 5 ] [ 6 ] It is used as a low calorie sweetener as it is poorly absorbed by the intestines . [ 5 ] As a medication, it is used to decrease pressure in the eyes, as in glaucoma , and to lower increased intracranial pressure .
If there is an intact blood–brain barrier, osmotherapy (mannitol or hypertonic saline) may be used to decrease ICP. [33] It is unclear whether mannitol or hypertonic saline is superior, or if they improve outcomes. [34] [35] Struggling, restlessness, and seizures can increase metabolic demands and oxygen consumption, as well as increasing ...
Hypertonic saline may be preferable to mannitol in persons with hypovolemia or hyponatremia. [44] Mannitol is an alcohol derivative of simple sugar mannose, and is historically the most commonly used osmotic diuretic. [3] Mannitol acts as an inert solute in the blood, decreasing ICP through osmosis as discussed above. [44]
Such agents can be used to reduce intracranial pressure and to promote prompt removal of renal toxins. The prototypical osmotic diuretic is mannitol. [5] Mannitol lowers the intra cranial pressure through two effects in the brain. The first, rheological effect, reduces blood viscosity, and promotes plasma expansion and cerebral oxygen delivery.
Rapid lowering of the blood pressure using antihypertensive therapy for those with hypertensive emergency can have higher functional recovery at 90 days post intracerebral haemorrhage, when compared to those who undergone other treatments such as mannitol administration, reversal of anticoagulation (those previously on anticoagulant treatment ...
An induced coma – also known as a medically induced coma (MIC), barbiturate-induced coma, or drug-induced coma – is a temporary coma (a deep state of unconsciousness) brought on by a controlled dose of an anesthetic drug, often a barbiturate such as pentobarbital or thiopental.
Excessive losses of water from the urinary tract – which may be caused by glycosuria, or other osmotic diuretics (e.g., mannitol) – leads to a combination of sodium and free water losses. [citation needed] Water losses associated with extreme sweating. [citation needed]
Lactitol, erythritol, sorbitol, xylitol, mannitol, and maltitol are all classified sugar alcohols (lactitol and maltitol are in fact disaccharide alcohols, since they contain one intact sugar). [1] The U.S. Food and Drug Administration (FDA) classifies sugar alcohols as " generally recognized as safe " (GRAS).