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In hematology, effective circulating volume (ECV) is the volume of arterial blood effectively perfusing tissue. [ 1 ] [ 2 ] ECV is a dynamic quantity and not a measurable, distinct compartment. [ 1 ] This concept is useful for discussion of cardiovascular and renal physiology.
FE Na can be useful in the evaluation of acute kidney failure in the context of low urine output. Low fractional excretion indicates sodium retention by the kidney, suggesting pathophysiology extrinsic to the urinary system such as volume depletion or decrease in effective circulating volume (e.g. low output heart failure).
Renal causes include overuse of diuretics, or trauma or disease of the kidney. Extrarenal causes include bleeding, burns, and any causes of edema (e.g. congestive heart failure, liver failure). [citation needed] Intravascular volume depletion is divided into three types based on the blood sodium level:
Volume contraction is a decrease in the volume of body fluid, including the dissolved substances that maintain osmotic balance . The loss of the water component of body fluid is specifically termed dehydration .
If a person has high total body water (such as due to heart failure or kidney disease) they may be placed on fluid restriction, salt restriction, and treated with a diuretic. [3] If a person has a normal volume of total body water, they may be placed on fluid restriction alone.
EABV can be reduced, therefore, by factors which reduce actual arterial blood volume (hemorrhage, dehydration), increase arterial vascular capacitance (cirrhosis, sepsis) or reduce cardiac output (congestive heart failure). EABV can be reduced in the setting of low, normal, or high actual blood volume.
If fluid loss is greater than fluid gain (for example if the patient vomits and has diarrhea), the patient is said to be in negative fluid balance. In this case, fluid is often given intravenously to compensate for the loss. On the other hand, a positive fluid balance (where fluid gain is greater than fluid loss) might suggest a problem with ...
The glomerular filtration rate (GFR) describes the volume of fluid filtered from the renal (kidney) glomerular capillaries into the Bowman's capsule per unit time. [3] Creatinine clearance (C Cr ) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR.