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The area under the effect curve (AUEC) is an integral of the effect of a drug over time, estimated as a previously-established function of concentration. It was proposed to be used instead of AUC in animal-to-human dose translation, as computer simulation shows that it could cope better with half-life and dosing schedule variations than AUC.
Taking an example, the area under the curve y = x 2 over [0, 2] can be procedurally computed using Riemann's method. The interval [0, 2] is firstly divided into n subintervals, each of which is given a width of 2 n {\displaystyle {\tfrac {2}{n}}} ; these are the widths of the Riemann rectangles (hereafter "boxes").
A classification model (classifier or diagnosis [7]) is a mapping of instances between certain classes/groups.Because the classifier or diagnosis result can be an arbitrary real value (continuous output), the classifier boundary between classes must be determined by a threshold value (for instance, to determine whether a person has hypertension based on a blood pressure measure).
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This free software had an earlier incarnation, Macsyma. Developed by Massachusetts Institute of Technology in the 1960s, it was maintained by William Schelter from 1982 to 2001. In 1998, Schelter obtained permission to release Maxima as open-source software under the GNU General Public license and the source code was released later that year ...
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