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The cell cycle inhibitor p27kip1 has also been found to encourage regrowth of cochlear hair cells in mice following genetic deletion or knock down with siRNA targeting p27. [36] [37] Research on hair cell regeneration may bring us closer to clinical treatment for human hearing loss caused by hair cell damage or death.
For one, the tall hair cell is very similar in function to that of the inner hair cell, and the short hair cell, lacking afferent auditory-nerve fiber innervation, resembles the outer hair cell. One unavoidable difference, however, is that while all hair cells are attached to a tectorial membrane in birds, only the outer hair cells are attached ...
The organ of Corti is located in the scala media of the cochlea of the inner ear between the vestibular duct and the tympanic duct and is composed of mechanosensory cells, known as hair cells. [2] Strategically positioned on the basilar membrane of the organ of Corti are three rows of outer hair cells (OHCs) and one row of inner hair cells ...
The cochlear amplifier is a positive feedback mechanism within the cochlea that provides acute sensitivity in the mammalian auditory system. [1] The main component of the cochlear amplifier is the outer hair cell (OHC) which increases the amplitude and frequency selectivity of sound vibrations using electromechanical feedback. [2] [3] [4]
[5] [6] Furthermore, Hensen's cells are also able to regenerate the damaged hair cells in some vertebrates; they undergo phagocytosis to eject the dead or injured hair cells, and reproduce both new hair cells and supporting cells into the cell cycle. One of the reasons is that the supporting cells are differentiated by the embryonic hair cells ...
Hair cells and supporting cells are both located in the cochlea inside the inner ear. [1] [2] In mammals, hair cells are located in the Organ of Corti and convert energy from sound waves and physical movement into electrical signals. [2]
The stria vascularis produces endolymph for the scala media, one of the three fluid-filled compartments of the cochlea. [4] This maintains the ion balance of the endolymph that surround inner hair cells and outer hair cells of the organ of Corti. [4] It secretes lots of K +, [1] [4] and may also secrete H +. [1]
The hair cells are attached to the basilar membrane, and with the moving of the basilar membrane, the tectorial membrane and the hair cells are also moving, with the stereocilia bending with the relative motion of the tectorial membrane. This can cause opening and closing of the mechanically gated potassium channels on the cilia of the hair ...
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