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The classical cannabinoids are concentrated in a viscous resin produced in structures known as glandular trichomes. At least 113 different cannabinoids have been isolated from the Cannabis plant. [6] All classes derive from cannabigerol-type (CBG) compounds and differ mainly in the way this precursor is cyclized. [21]
Cannabinoids (/ k ə ˈ n æ b ə n ɔɪ d z ˌ ˈ k æ n ə b ə n ɔɪ d z /) are compounds found in the cannabis plant or synthetic compounds that can interact with the endocannabinoid system. [ 1 ] [ 2 ] The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (Delta-9-THC), the primary intoxicating compound in cannabis .
A dried cannabis flower. The short-term effects of cannabis are caused by many chemical compounds in the cannabis plant, including 113 [clarification needed] different cannabinoids, such as tetrahydrocannabinol, and 120 terpenes, [1] which allow its drug to have various psychological and physiological effects on the human body.
Cannabinoids and their K i values [a] Name Class K i / nM at CB 1 K i / nM at CB 2 Selectivity Structure JWH-004: Naphthoylindole: 48 ± 13: 4 ± 1.5: CB 2 (12x) JWH ...
Pages in category "Cannabinoids" The following 200 pages are in this category, out of approximately 301 total. This list may not reflect recent changes.
THC, along with its double bond isomers and their stereoisomers, [62] is one of only three cannabinoids scheduled by the UN Convention on Psychotropic Substances (the other two are dimethylheptylpyran and parahexyl). It was listed under Schedule I in 1971, but reclassified to Schedule II in 1991 following a recommendation from the WHO.
The production of the cannabinoids THC and CBD are a result of a series of chemical reactions, and are just two types of over a hundred that are known. [9] [10] Inside the transcriptomes of glandular trichomes in the cannabis plant, the pathway for cannabinoid production takes place. [9]
The two cannabinoids usually produced in greatest abundance are cannabidiol (CBD) and/or Δ 9-tetrahydrocannabinol (THC), but only THC is psychoactive. [55] Since the early 1970s, Cannabis plants have been categorized by their chemical phenotype or "chemotype", based on the overall amount of THC produced, and on the ratio of THC to CBD. [56]