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Deoxycytidine is a deoxyribonucleoside, a component of deoxyribonucleic acid. It is similar to the ribonucleoside cytidine , but with one hydroxyl group removed from the C2' position. Deoxycytidine can be phosphorylated at C5' of the deoxyribose by deoxycytidine kinase , converting it to deoxycytidine monophosphate (dCMP), a DNA precursor.
Decitabine (i.e., 5-aza-2′-deoxycytidine), sold under the brand name Dacogen among others, acts as a nucleic acid synthesis inhibitor. [4] It is a medication for the treatment of myelodysplastic syndromes, a class of conditions where certain blood cells are dysfunctional, and for acute myeloid leukemia (AML). [5] Chemically, it is a cytidine ...
Deoxycytidine kinase (dCK) is an enzyme which is encoded by the DCK gene in humans. [5] ... (12-15 residues) that connects helices 2 and 3. ...
Gemcitabine is a synthetic pyrimidine nucleoside prodrug—a nucleoside analog in which the hydrogen atoms on the 2' carbon of deoxycytidine are replaced by fluorine atoms. [2] [23] [24] The synthesis described and pictured below is the original synthesis done in the Eli Lilly Company labs.
Deoxycytidine monophosphate is a molecule of interest in treating genetic disorders such as thymidine kinase 2 (TK2) deficiency.In the case of TK2 deficiency, dCMP in conjunction with deoxythymidine monophosphate (dTMP) to bypass the deficiency in the TK2 enzyme. [2]
Hold for 2 counts. Lean forward slightly. Cough twice—2 short coughs. Relax for a few seconds. Repeat the steps as needed. How to get rid of chest congestion using medication.
Deoxycytidine diphosphate is a nucleoside diphosphate. It is related to the common nucleic acid CTP, or cytidine triphosphate, with the -OH group on the 2' carbon on the nucleotide's pentose removed (hence the deoxy- part of the name), and with one fewer phosphoryl group than CTP . 2'-Deoxycytidine diphosphate is abbreviated as dCDP. [1]
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