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Piebaldism refers to the absence of mature melanin-forming cells (melanocytes) in certain areas of the skin and hair. It is a rare autosomal dominant disorder of melanocyte development. [ 2 ] : 867 Common characteristics include a congenital white forelock , scattered normal pigmented and hypopigmented macules and a triangular shaped ...
Some genetic conditions that result in a "leucistic" appearance include piebaldism, Waardenburg syndrome, vitiligo, Chédiak–Higashi syndrome, flavism, isabellinism, xanthochromism, axanthism, amelanism, and melanophilin mutations. Pale patches of skin, feathers, or fur (often referred to as "depigmentation") can also result from injury.
Vitiligo (/ ˌ v ɪ t ɪ ˈ l aɪ ɡ oʊ /, vit-il-eye-goh) is a chronic autoimmune disorder that causes patches of skin to lose pigment or color. [1] The cause of vitiligo is unknown, but it may be related to immune system changes, genetic factors, stress, or sun exposure. [5] [6] Treatment options include topical medications, light therapy ...
Vitiligo is a condition that causes the skin to begin to lose its pigmentation—or color—for no apparent reason, resulting in white patches that are especially noticeable in people whose skin ...
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Poliosis occurs in several genetic syndromes such as piebaldism, Waardenburg syndrome, neurofibromatosis type I, and tuberous sclerosis. [16] It can also occur in conditions such as vitiligo , Vogt–Koyanagi–Harada disease , alopecia areata , and sarcoidosis , and in association with neoplasms and some medications.
Vitiligo: Topical steroids, including calcineurin inhibitors. Patients can also have transplants if they are stable or a depigmentation with topical MBEH if the patient has widespread discoloration. Chemical or drug induced leukoderma: Avoidance of causative agent with subsequent treatment similar to vitiligo. Piebaldism: None; occasionally ...
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