Search results
Results From The WOW.Com Content Network
The mechanism for base-catalyzed aldol condensation can be seen in the image below. A mechanism for aldol condensation in basic conditions, which occurs via enolate intermediates and E1CB elimination. The process begins when a free hydroxide (strong base) strips the highly acidic proton at the alpha carbon of the aldehyde.
The scheme shows a simple mechanism for the base-catalyzed aldol reaction of an aldehyde with itself. Simple mechanism for base-catalyzed aldol reaction of an aldehyde with itself Although only a catalytic amount of base is required in some cases, the more usual procedure is to use a stoichiometric amount of a strong base such as LDA or NaHMDS .
After which it may undergo dehydration to give a unsaturated carbonyl compound, the aldol condensation product. The scheme shows a simple mechanism for the base-catalyzed aldol reaction of an aldehyde with itself. Base-catalyzed aldol reaction. Simple mechanism for base-catalyzed aldol reaction of an aldehyde with itself. Base-catalyzed dehydration
The Hajos–Parrish–Eder–Sauer–Wiechert and Barbas-List [1] reactions in organic chemistry are a family of proline-catalysed asymmetric aldol reactions.. In the 1970s, two research groups discovered (and published) almost simultaneously their discoveries of two related intramolecular reactions: Zoltan Hajos and David Parrish at Hoffmann-La Roche [2] [3] and Rudolf Wiechert et al at ...
Mukaiyama aldol in taxol synthesis. and a second one with an amine chiral ligand and a triflate salt catalyst: Mukaiyama asymmetric aldol taxol. Utilization of chiral Lewis acid complexes and Lewis bases in asymmetric catalytic processes is the fastest-growing area in the usage of the Mukaiyama aldol reaction. [3]
The Japp–Maitland condensation is an organic reaction and a type of Aldol reaction and a tandem reaction.In a reaction between the ketone 2-pentanone and the aldehyde benzaldehyde catalyzed by base the bis Aldol adduct is formed first.
Proline-catalyzed aldol additions proceed via a six-membered enamine transition state according to the Zimmerman-Traxler model. Addition of 20-30 mol% proline to acetone or hydroxyacetone catalyzes their addition to a diverse set of aldehydes with high (>99%) enantioselectivity yielding diol products.
A common side-reaction of the Oppenauer oxidation is the base-catalyzed aldol condensation of aldehyde product, which have α-hydrogens to form either β-hydroxy aldehydes or α, ß-unsaturated aldehydes. [13] An Oppenauer oxidation of aldehyde